SEMA3F-AS1

Across TCGA pan-cancer cohorts, SEMA3F-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SEMA3F-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SEMA3F-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEMA3F-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

BRCA, BLCA, and UVM are the cancer types where SEMA3F-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.964	0.845	<.001	67	view →
BLCA	OS	Median	II,III,IV	0.665	0.545	.002	47	view →
UVM	DFS	Quartile	III,IV	0.240	0.910	.001	38	view →
ACC	DFS	Tertile	IV	0.095	0.564	.001	37	view →
PRAD	DFS	Median	All	0.826	0.930	<.001	28	view →
UCS	DFS	Tertile	IV	0.975	0.237	.024	24	view →
KIRC	DFS	Median	II,III,IV	0.413	0.602	.004	24	view →
LUAD	DFS	Tertile	IV	0.290	1.000	.014	18	view →
PAAD	OS	Median	All	0.570	0.409	.017	14	view →
LGG	DFS	Tertile	All	0.755	0.896	<.001	13	view →
MESO	DFS	Median	IV	0.178	0.491	.008	12	view →
CESC	DFS	Median	II,III,IV	0.349	0.727	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SEMA3F-AS1–BRCA (OS)

Open the BRCA breakdown →