SEMA3F-AS1

Across TCGA pan-cancer cohorts, SEMA3F-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SEMA3F-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SEMA3F-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA3F-AS1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where SEMA3F-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3F-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−0.985	<.001	7	view →
LUAD	All	All	−0.496	<.001	7	view →
BRCA	All	III,IV	−0.587	<.001	6	view →
LIHC	All	All	+0.183	<.001	6	view →
CHOL	All	All	+0.852	<.001	3	view →
HNSC	Male	All	−0.131	.039	2	view →
KICH	All	All	−0.157	.045	1	view →
COAD	All	All	+0.149	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SEMA3F-AS1–LUSC

Open the LUSC breakdown →