SEMA3D

Across TCGA pan-cancer cohorts, SEMA3D Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SEMA3D data layer compared with 28 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEMA3D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SEMA3D expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LIHC, and DLBC are the cancer types where SEMA3D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.619	.002	36	view →
LIHC	DFS	Median	III,IV	0.076	0.360	.001	24	view →
DLBC	OS	Median	All	0.053	0.936	<.001	9	view →
STAD	OS	Median	IV	0.052	0.541	.003	9	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
PRAD	DFS	Median	All	0.617	0.886	.038	6	view →
BRCA	OS	Median	All	0.635	0.963	.012	4	view →
LUAD	DFS	Median	All	1.000	0.802	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SEMA3D–UCEC (DFS)

Open the UCEC breakdown →