SEMA3C

Across TCGA pan-cancer cohorts, SEMA3C Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SEMA3C data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SEMA3C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEMA3C expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

OV, UCEC, and LUAD are the cancer types where SEMA3C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.076	0.844	<.001	48	view →
UCEC	DFS	Median	All	1.000	0.618	.001	36	view →
LUAD	OS	Median	III,IV	0.271	0.670	.012	21	view →
LIHC	OS	Median	III,IV	0.118	0.615	.003	14	view →
DLBC	OS	Median	All	0.624	0.928	.005	13	view →
SARC	OS	Median	All	0.022	0.861	<.001	12	view →
BLCA	OS	Median	II,III,IV	1.000	0.412	.025	12	view →
COAD	OS	Median	III,IV	0.208	0.791	.008	11	view →
SKCM	DFS	Median	All	0.087	0.757	<.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SEMA3C–OV (OS)

Open the OV breakdown →