SEMA3C

Across TCGA pan-cancer cohorts, SEMA3C mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SEMA3C data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SEMA3C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEMA3C expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where SEMA3C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.761	0.426	.001	59	view →
PDAC	DFS	Quartile	III,IV	0.232	0.730	.006	15	view →
LUAD	OS	Median	II,III,IV	0.429	0.911	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SEMA3C–HNSC (DFS)

Open the HNSC breakdown →