SEMA3C

Across TCGA pan-cancer cohorts, SEMA3C mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SEMA3C’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where SEMA3C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA3C is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where SEMA3C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	+0.595	<.001	7	view →
LSCC	All	All	+0.169	.001	6	view →
LUAD	All	All	−0.103	.015	5	view →
CCRCC	All	All	+0.780	.030	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SEMA3C–PDAC

Open the PDAC breakdown →