SEMA3A

Across TCGA pan-cancer cohorts, SEMA3A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEMA3A data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEMA3A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SEMA3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, KIRC, and HNSC are the cancer types where SEMA3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.963	0.825	.011	30	view →
KIRC	DFS	Median	All	0.122	0.624	.030	6	view →
HNSC	DFS	Median	II,III,IV	1.000	0.584	.025	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SARC	OS	Median	All	0.241	0.766	.022	3	view →
SKCM	OS	Median	III,IV	0.307	0.739	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEMA3A–UCEC (DFS)

Open the UCEC breakdown →