SEMA3A

Across TCGA pan-cancer cohorts, SEMA3A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SEMA3A data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEMA3A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEMA3A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD and LSCC are the cancer types where SEMA3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.398	1.000	.038	5	view →
LSCC	DFS	Median	II,III,IV	0.888	0.221	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SEMA3A–LUAD (OS)

Open the LUAD breakdown →