SEMA3A

Across TCGA patient cohorts, SEMA3A mutation is significantly associated with the RNA expression of many other genes, with 4,597 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3A-associated genes across cancer lineages are RNA5SP413, RNA5SP423, and SPANXN2. Each is linked with SEMA3A in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA3A-to-partner and partner-to-SEMA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by SEMA3A-low versus SEMA3A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3A→partner) and Y-score (partner→SEMA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP413 →	+0.217	+5.852	<.001	<.001	3	3
UCEC	RNA5SP423 →	+0.408	+1.348	.002	.007	3	3
CESC	SPANXN2 →	+0.051	+4.247	<.001	.007	3	3
LGG	RN7SKP286 →	+0.164	+7.977	<.001	.007	3	3
UCEC	FCGR1A →	+0.525	+1.971	<.001	<.001	3	3
UCEC	SLC7A11 →	+0.729	+1.369	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,597 associations by consensus.

RNA5SP413 by SEMA3A expression — CESC

Explore this box plot interactively →