SEMA3A

Across TCGA patient cohorts, SEMA3A mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3A-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and p62 Lck ligand. Each is linked with SEMA3A in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA3A-to-partner and partner-to-SEMA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SEMA3A-low versus SEMA3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3A→partner) and Y-score (partner→SEMA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.143	-1.765	.004	.011	3	4
UCEC	Notch1 →	+0.142	+1.530	<.001	.004	3	3
UCEC	p62 Lck ligand →	+0.345	+2.584	<.001	<.001	3	3
UCEC	ARID1A →	-0.120	-1.056	.032	.047	3	3
COAD	ATM →	-0.593	-3.313	.001	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.697	+1.736	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

JNK_pT183_Y185 by SEMA3A expression — UCEC

Explore this box plot interactively →