SEMA3A

Across TCGA cell cohorts, SEMA3A mutation is significantly associated with the mutation status of many other genes, with 4,883 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA3A-associated genes across cancer lineages are TECPR1, GCN1, and TEP1. Each is linked with SEMA3A in more than 4 cancer types. Because this analysis shows association rather than direction, both SEMA3A-to-partner and partner-to-SEMA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TECPR1 grouped by SEMA3A-low versus SEMA3A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3A→partner) and Y-score (partner→SEMA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TECPR1 →	+5.392	+5.392	.004	.004	1	5
BREAST	GCN1 →	+4.297	+4.857	.009	.009	1	4
BLOOD_Leukemia	TEP1 →	+2.787	+3.962	<.001	<.001	1	4
SKIN	UBE4B →	+3.906	+3.316	.004	.004	1	4
LUNG_SCLC	RASAL2 →	+4.502	+5.066	.007	.007	1	4
SKIN	CIC →	+3.321	+3.035	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,883 associations by consensus.

TECPR1 by SEMA3A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →