SEM1

Across TCGA patient cohorts, SEM1 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEM1-associated genes across cancer lineages are RNA5SP497, H4C13, and RNA5SP412. Each is linked with SEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEM1-to-partner and partner-to-SEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP497 grouped by SEM1-low versus SEM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEM1→partner) and Y-score (partner→SEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP497 →	+0.743	+4.034	<.001	.001	3	2
UCEC	H4C13 →	+1.121	+3.917	<.001	.001	3	1
UCEC	RNA5SP412 →	+0.812	+2.967	<.001	.007	3	1
UCEC	MIR7845 →	+0.639	+2.838	<.001	.009	3	1
HNSC	DEFB107B →	+0.104	+7.954	<.001	.008	3	1
HNSC	RNA5SP232 →	+0.299	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

RNA5SP497 by SEM1 expression — UCEC

Explore this box plot interactively →