SELPLG

Across TCGA patient cohorts, SELPLG mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELPLG-associated genes across cancer lineages are RNU6-660P, RNU6-898P, and GPX4. Each is linked with SELPLG in more than 2 cancer types. Because this analysis shows association rather than direction, both SELPLG-to-partner and partner-to-SELPLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-660P grouped by SELPLG-low versus SELPLG-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELPLG→partner) and Y-score (partner→SELPLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-660P →	+0.322	+4.584	<.001	.004	3	3
HNSC	RNU6-898P →	+0.388	+5.578	<.001	.004	3	2
UCEC	GPX4 →	+0.551	+3.141	.001	<.001	3	2
LUSC	OR2Y1 →	+0.194	+5.005	<.001	.002	3	2
LUSC	RNA5SP125 →	+0.248	+5.005	<.001	.002	3	2
LUSC	RNU6-742P →	+0.487	+3.169	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

RNU6-660P by SELPLG expression — LUSC

Explore this box plot interactively →