SELP

Across TCGA cell cohorts, SELP mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SELP-associated genes across cancer lineages are ZNF723, CD300H, and OR10D3. Each is linked with SELP in more than 1 cancer types. Because this analysis shows association rather than direction, both SELP-to-partner and partner-to-SELP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF723 grouped by SELP-low versus SELP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELP→partner) and Y-score (partner→SELP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF723 →	+0.345	+3.621	<.001	.005	3	2
LUNG_NSCLC_LUAD	CD300H →	+0.235	+3.882	<.001	.003	3	2
LUNG_NSCLC_LUSC	OR10D3 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TEX28 →	+0.183	+4.643	<.001	.008	3	1
OESOPHAGUS	GPR101 →	+0.070	+4.906	<.001	.006	3	1
SKIN	MYBPC3 →	+0.010	+4.273	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

ZNF723 by SELP expression — LUNG_SCLC

Explore this box plot interactively →