SELENOS

Across TCGA patient cohorts, SELENOS protein abundance is significantly associated with the RNA expression of many other genes, with 11,595 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SELENOS-associated genes across cancer lineages are TIE1, C19orf44, and HDAC5. Each is linked with SELENOS in more than 3 cancer types. Because this analysis shows association rather than direction, both SELENOS-to-partner and partner-to-SELENOS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SELENOS versus TIE1 in CCRCC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOS→partner) and Y-score (partner→SELENOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TIE1 →	-0.750	-0.361	.005	.001	3	4
CCRCC	C19orf44 →	-0.431	-0.388	.002	.001	3	3
BRCA	HDAC5 →	-0.543	-0.301	<.001	.007	3	3
BRCA	AMOTL2 →	-0.814	-0.448	.001	.001	3	3
LUAD	ATP13A4 →	-1.828	-0.509	<.001	<.001	3	3
BRCA	FAM161B →	-0.674	-0.413	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,595 associations by consensus.

SELENOS vs TIE1 — CCRCC

Explore this scatter interactively →