SELENOS

Across TCGA pan-cancer cohorts, SELENOS RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SELENOS data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SELENOS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SELENOS expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

UVM, KICH, and ACC are the cancer types where SELENOS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.279	0.740	<.001	123	view →
KICH	DFS	Tertile	III,IV	0.236	1.000	.002	91	view →
ACC	DFS	Median	All	0.200	0.721	<.001	88	view →
UCEC	OS	Quartile	III,IV	0.805	0.401	<.001	74	view →
HNSC	DFS	Quartile	All	0.235	0.418	<.001	72	view →
CESC	DFS	Median	III,IV	0.575	0.871	.003	50	view →
OV	DFS	Quartile	IV	0.538	0.278	.008	46	view →
BRCA	OS	Tertile	IV	0.322	0.897	.002	37	view →
ESCA	DFS	Median	III,IV	0.298	0.576	<.001	36	view →
KIRC	DFS	Median	IV	0.670	0.249	.002	34	view →
LGG	OS	Median	All	0.856	0.931	<.001	33	view →
SKCM	OS	Median	All	0.934	0.805	.001	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SELENOS–UVM (DFS)

Open the UVM breakdown →