SELENOP

Across TCGA cell cohorts, SELENOP mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SELENOP-associated genes across cancer lineages are TNP1, OR4C12, and HMHB1. Each is linked with SELENOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SELENOP-to-partner and partner-to-SELENOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by SELENOP-low versus SELENOP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOP→partner) and Y-score (partner→SELENOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.172	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1
SKIN	HMHB1 →	+0.038	+4.022	<.001	.006	3	1
SKIN	CCR8 →	+0.027	+3.345	<.001	.007	3	1
SKIN	KRTAP22-2 →	+0.083	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TNP1 by SELENOP expression — LARGE_INTESTINE

Explore this box plot interactively →