SELENOO

Across TCGA patient cohorts, SELENOO mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELENOO-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Rad50. Each is linked with SELENOO in more than 2 cancer types. Because this analysis shows association rather than direction, both SELENOO-to-partner and partner-to-SELENOO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SELENOO-low versus SELENOO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOO→partner) and Y-score (partner→SELENOO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.713	+2.321	.002	.033	3	3
COAD	MEK1 →	+0.272	+3.025	.008	.019	3	2
UCEC	Rad50 →	-0.263	-2.415	.007	.003	3	2
UCEC	EGFR_pY1068 →	-0.279	-2.584	.005	.010	3	1
UCEC	p27_pT198 →	+0.088	+2.321	.042	.034	3	1
UCEC	p62 Lck ligand →	+0.432	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Caspase-7-cleavedD198 by SELENOO expression — UCEC

Explore this box plot interactively →