SELENOI

Across TCGA patient cohorts, SELENOI mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SELENOI-associated genes across cancer lineages are EGFR, FOXO3a_pS318_S321, and ACC1. Each is linked with SELENOI in more than 1 cancer types. Because this analysis shows association rather than direction, both SELENOI-to-partner and partner-to-SELENOI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SELENOI-low versus SELENOI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SELENOI→partner) and Y-score (partner→SELENOI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.141	-1.502	.016	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.212	.013	.010	3	1
UCEC	ACC1 →	+0.283	+2.183	.034	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.584	.003	.010	3	1
UCEC	JNK2 →	+0.271	+2.247	<.001	.001	3	1
UCEC	Ku80 →	+0.284	+3.405	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR by SELENOI expression — UCEC

Explore this box plot interactively →