SEL1L2

Across TCGA patient cohorts, SEL1L2 mutation is significantly associated with the RNA expression of many other genes, with 3,141 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEL1L2-associated genes across cancer lineages are IGHD5-12, GZMH, and CHAC1. Each is linked with SEL1L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEL1L2-to-partner and partner-to-SEL1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-12 grouped by SEL1L2-low versus SEL1L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L2→partner) and Y-score (partner→SEL1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD5-12 →	+0.269	+2.368	<.001	.007	3	4
UCEC	GZMH →	+1.282	+2.776	<.001	<.001	3	3
UCEC	CHAC1 →	+0.590	+2.069	.002	<.001	3	3
UCEC	GZMA →	+1.162	+2.069	<.001	<.001	3	3
READ	MIR4790 →	+0.526	+5.096	<.001	.002	3	3
UCEC	NDUFA6 →	+0.512	+2.069	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,141 associations by consensus.

IGHD5-12 by SEL1L2 expression — UCEC

Explore this box plot interactively →