SEL1L2

Across TCGA pan-cancer cohorts, SEL1L2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SEL1L2 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SEL1L2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEL1L2 expression acts as an unfavorable survival marker, although some lineages such as UVM and CESC show a favorable association.

UVM, LAML, and READ are the cancer types where SEL1L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.809	0.355	.001	96	view →
LAML	DFS	Tertile	All	0.439	0.693	<.001	32	view →
READ	OS	Quartile	III,IV	0.450	0.806	.009	31	view →
LGG	OS	Quartile	All	0.360	0.570	<.001	27	view →
CESC	DFS	Median	II,III,IV	0.605	0.249	.014	26	view →
THCA	DFS	Tertile	All	0.981	0.910	.002	26	view →
CHOL	OS	Tertile	All	0.848	0.441	.007	20	view →
ACC	OS	Median	All	0.924	0.711	.009	16	view →
BLCA	OS	Median	III,IV	0.280	0.504	.027	13	view →
PAAD	DFS	Median	All	0.555	0.423	.018	12	view →
ESCA	OS	Quartile	III,IV	0.726	0.375	.014	12	view →
KIRP	DFS	Median	II,III,IV	0.713	0.291	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SEL1L2–UVM (OS)

Open the UVM breakdown →