SEL1L2

Across TCGA patient cohorts, SEL1L2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEL1L2-associated genes across cancer lineages are eIF4E, ERK2, and FoxM1. Each is linked with SEL1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEL1L2-to-partner and partner-to-SEL1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SEL1L2-low versus SEL1L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L2→partner) and Y-score (partner→SEL1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.137	+1.392	.049	.019	3	2
UCEC	ERK2 →	+0.196	+1.392	.001	.019	3	2
UCEC	FoxM1 →	+0.173	+1.392	.042	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.146	-1.638	.008	.006	3	2
UCEC	Notch1 →	+0.110	+1.652	.018	.006	3	2
COAD	p53 →	-0.341	-3.000	.025	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by SEL1L2 expression — UCEC

Explore this box plot interactively →