SEL1L2

Across TCGA cell cohorts, SEL1L2 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEL1L2-associated genes across cancer lineages are MYOD1, PCDH11Y, and KRTAP10-5. Each is linked with SEL1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEL1L2-to-partner and partner-to-SEL1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by SEL1L2-low versus SEL1L2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L2→partner) and Y-score (partner→SEL1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MYOD1 →	+0.006	+4.906	<.001	.006	3	1
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
BREAST	KRTAP10-5 →	+0.015	+4.781	<.001	.003	3	1
STOMACH	OR4S2 →	+0.020	+5.285	<.001	.003	3	1
BLOOD_Lymphoma	TEX50 →	+0.042	+4.643	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.163	+3.667	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

MYOD1 by SEL1L2 expression — OESOPHAGUS

Explore this box plot interactively →