SEL1L2

Across TCGA cell cohorts, SEL1L2 mutation is significantly associated with the mutation status of many other genes, with 4,165 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEL1L2-associated genes across cancer lineages are COL4A4, PLXNA4, and CFTR. Each is linked with SEL1L2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SEL1L2-to-partner and partner-to-SEL1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL4A4 grouped by SEL1L2-low versus SEL1L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEL1L2→partner) and Y-score (partner→SEL1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COL4A4 →	+2.056	+2.313	.005	.005	1	5
KIDNEY	PLXNA4 →	+5.000	+5.000	.006	.006	1	4
LUNG_NSCLC_LUAD	CFTR →	+3.396	+4.078	<.001	<.001	1	4
LUNG_NSCLC_LUAD	KDM5A →	+2.911	+3.750	.002	.002	1	4
BLOOD_Lymphoma	ZFR →	+4.584	+4.584	.007	.007	1	4
LARGE_INTESTINE	CAMKK2 →	+5.056	+3.478	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,165 associations by consensus.

COL4A4 by SEL1L2 expression — LARGE_INTESTINE

Explore this box plot interactively →