SEL1L

Across TCGA pan-cancer cohorts, SEL1L Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEL1L data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SEL1L Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEL1L expression acts as an unfavorable survival marker.

CESC, ACC, and SCLC are the cancer types where SEL1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	30	view →
ACC	DFS	Median	All	0.057	0.667	<.001	15	view →
SCLC	DFS	Median	III,IV	0.137	0.546	.042	6	view →
LUSC	OS	Median	All	0.081	0.818	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEL1L–CESC (DFS)

Open the CESC breakdown →