SEL1L

Across TCGA pan-cancer cohorts, SEL1L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEL1L data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SEL1L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEL1L expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where SEL1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	28	view →
CCRCC	DFS	Quartile	III,IV	0.407	0.847	.010	12	view →
PDAC	DFS	Quartile	All	0.342	0.509	.019	4	view →
GBM	OS	Median	All	0.463	0.298	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEL1L–HNSC (OS)

Open the HNSC breakdown →