SEH1L

Across TCGA pan-cancer cohorts, SEH1L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEH1L data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEH1L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEH1L expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where SEH1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.455	1.000	.010	18	view →
HNSC	DFS	Quartile	IV	0.624	0.925	.010	5	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	5	view →
LSCC	DFS	Quartile	II,III,IV	0.929	0.494	.026	3	view →
PDAC	OS	Tertile	II,III,IV	0.651	0.914	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SEH1L–UCEC (DFS)

Open the UCEC breakdown →