SEH1L

Across TCGA pan-cancer cohorts, SEH1L RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SEH1L’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where SEH1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEH1L is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

STAD, LIHC, and HNSC are the cancer types where SEH1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEH1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	II,III,IV	+1.152	<.001	9	view →
LIHC	Male	II,III,IV	+0.857	<.001	8	view →
HNSC	Male	All	+0.713	<.001	8	view →
LUSC	Male	III,IV	+1.075	<.001	7	view →
COAD	All	II,III,IV	+0.533	<.001	7	view →
KIRC	All	All	+0.261	<.001	7	view →
KICH	Female	All	−1.004	<.001	6	view →
BRCA	All	II,III,IV	+0.308	<.001	6	view →
CHOL	Male	All	+1.515	<.001	5	view →
LUAD	Male	II,III,IV	+0.557	<.001	5	view →
READ	All	III,IV	+0.790	.021	2	view →
UCEC	All	II,III,IV	+0.639	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SEH1L–STAD

Open the STAD breakdown →