SEH1L

Across TCGA patient cohorts, SEH1L mutation is significantly associated with the RNA expression of many other genes, with 1,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEH1L-associated genes across cancer lineages are RNA5SP138, MIR548AI, and LINC02079. Each is linked with SEH1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SEH1L-to-partner and partner-to-SEH1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP138 grouped by SEH1L-low versus SEH1L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEH1L→partner) and Y-score (partner→SEH1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP138 →	+0.274	+7.640	<.001	.009	3	2
UCEC	MIR548AI →	+0.154	+3.736	<.001	.009	3	1
UCEC	LINC02079 →	+0.101	+2.904	<.001	.009	3	1
UCEC	AARSD1 →	+0.379	+3.332	.003	.005	3	1
UCEC	ASB16-AS1 →	+0.450	+3.329	.002	.005	3	1
UCEC	CIRBP-AS1 →	+0.884	+3.732	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,440 associations by consensus.

RNA5SP138 by SEH1L expression — BLCA

Explore this box plot interactively →