SEH1L

Across TCGA patient cohorts, SEH1L mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEH1L-associated genes across cancer lineages are GSK3-a-b, JNK_pT183_Y185, and Lck. Each is linked with SEH1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SEH1L-to-partner and partner-to-SEH1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3-a-b grouped by SEH1L-low versus SEH1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEH1L→partner) and Y-score (partner→SEH1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK3-a-b →	-0.126	-2.000	.038	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.150	-3.169	.047	.019	3	1
UCEC	Lck →	+0.191	+2.000	.035	.032	3	1
UCEC	Notch1 →	+0.177	+3.335	.005	.005	3	1
UCEC	p27_pT198 →	+0.119	+2.000	.013	.032	3	1
UCEC	p62 Lck ligand →	+0.359	+3.009	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GSK3-a-b by SEH1L expression — UCEC

Explore this box plot interactively →