SECISBP2L

Across TCGA patient cohorts, SECISBP2L mutation is significantly associated with the RNA expression of many other genes, with 3,452 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SECISBP2L-associated genes across cancer lineages are SLC25A4, FBXW5, and ECI1. Each is linked with SECISBP2L in more than 2 cancer types. Because this analysis shows association rather than direction, both SECISBP2L-to-partner and partner-to-SECISBP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A4 grouped by SECISBP2L-low versus SECISBP2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SECISBP2L→partner) and Y-score (partner→SECISBP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A4 →	+0.501	+1.680	<.001	<.001	3	3
UCEC	FBXW5 →	+0.375	+2.881	.001	<.001	3	3
UCEC	ECI1 →	+0.426	+3.212	<.001	<.001	3	3
UCEC	MRM3 →	+0.470	+1.890	<.001	<.001	3	3
UCEC	MRPL43 →	+0.227	+2.145	.005	<.001	3	3
UCEC	LAG3 →	+0.901	+1.847	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,452 associations by consensus.

SLC25A4 by SECISBP2L expression — UCEC

Explore this box plot interactively →