SECISBP2L

Across TCGA patient cohorts, SECISBP2L mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SECISBP2L-associated genes across cancer lineages are Di-Ras3, ASNS, and Mre11. Each is linked with SECISBP2L in more than 3 cancer types. Because this analysis shows association rather than direction, both SECISBP2L-to-partner and partner-to-SECISBP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by SECISBP2L-low versus SECISBP2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SECISBP2L→partner) and Y-score (partner→SECISBP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.136	-2.571	.001	<.001	3	4
STAD	ASNS →	+0.602	+3.000	.008	.036	3	3
UCEC	Mre11 →	-0.054	-1.651	.023	.019	3	3
UCEC	JNK_pT183_Y185 →	-0.183	-2.459	<.001	<.001	3	2
STAD	c-Kit →	-0.411	-3.000	.012	.036	3	2
STAD	4E-BP1 →	+0.576	+3.000	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Di-Ras3 by SECISBP2L expression — UCEC

Explore this box plot interactively →