SECISBP2L

Across TCGA cell cohorts, SECISBP2L mutation is significantly associated with the RNA expression of many other genes, with 908 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SECISBP2L-associated genes across cancer lineages are ACER1, OR13H1, and ZIC3. Each is linked with SECISBP2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SECISBP2L-to-partner and partner-to-SECISBP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by SECISBP2L-low versus SECISBP2L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SECISBP2L→partner) and Y-score (partner→SECISBP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACER1 →	+0.021	+4.977	<.001	.007	3	2
SKIN	OR13H1 →	+0.056	+4.977	<.001	.007	3	2
BLOOD_Lymphoma	ZIC3 →	+0.529	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OTOL1 →	+0.012	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5P2 →	+0.021	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	FAM47A →	+0.026	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 908 associations by consensus.

ACER1 by SECISBP2L expression — SKIN

Explore this box plot interactively →