SECISBP2L

Across TCGA cell cohorts, SECISBP2L mutation is significantly associated with the mutation status of many other genes, with 6,598 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SECISBP2L-associated genes across cancer lineages are ZMIZ2, RGL1, and ZFP64. Each is linked with SECISBP2L in more than 3 cancer types. Because this analysis shows association rather than direction, both SECISBP2L-to-partner and partner-to-SECISBP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMIZ2 grouped by SECISBP2L-low versus SECISBP2L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SECISBP2L→partner) and Y-score (partner→SECISBP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZMIZ2 →	+2.313	+2.056	.005	.005	1	4
LARGE_INTESTINE	RGL1 →	+2.465	+2.465	<.001	<.001	1	4
LARGE_INTESTINE	ZFP64 →	+2.050	+3.058	<.001	<.001	1	3
LARGE_INTESTINE	AKAP11 →	+4.510	+4.056	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	ATP2B4 →	+4.954	+4.392	.008	.008	1	3
LARGE_INTESTINE	PSD →	+3.188	+3.681	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,598 associations by consensus.

ZMIZ2 by SECISBP2L expression — LARGE_INTESTINE

Explore this box plot interactively →