SEC61G

Across TCGA pan-cancer cohorts, SEC61G Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SEC61G data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SEC61G Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEC61G expression acts as an unfavorable survival marker.

KIRP, SKCM, and COAD are the cancer types where SEC61G Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.188	0.903	<.001	21	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	16	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SEC61G–KIRP (OS)

Open the KIRP breakdown →