SEC61G

Across TCGA pan-cancer cohorts, SEC61G RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SEC61G’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEC61G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEC61G is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where SEC61G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC61G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.528	<.001	12	view →
KIRC	Male	IV	+1.443	<.001	12	view →
BLCA	All	All	+1.036	<.001	11	view →
LUAD	All	III,IV	+1.210	<.001	9	view →
KIRP	All	III,IV	+0.835	<.001	9	view →
LIHC	Male	II,III,IV	+1.202	<.001	8	view →
COAD	Male	II,III,IV	+0.613	<.001	8	view →
LUSC	Male	II,III,IV	+1.169	<.001	6	view →
STAD	Female	All	+1.055	<.001	6	view →
BRCA	All	III,IV	+0.915	<.001	6	view →
UCEC	All	All	+0.646	<.001	6	view →
THCA	All	All	−0.293	.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SEC61G–HNSC

Open the HNSC breakdown →