SEC61G

Across TCGA pan-cancer cohorts, SEC61G mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEC61G data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SEC61G mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SEC61G expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where SEC61G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	1.000	0.774	.002	34	view →
CCRCC	DFS	Quartile	All	0.955	0.638	.003	14	view →
GBM	DFS	Quartile	All	0.223	0.451	.003	7	view →
HNSC	DFS	Tertile	All	1.000	0.932	.027	5	view →
PDAC	DFS	Median	III,IV	0.760	0.569	.048	2	view →
LUAD	OS	Median	II,III,IV	0.812	0.445	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEC61G–LSCC (OS)

Open the LSCC breakdown →