SEC61G

Across TCGA patient cohorts, SEC61G protein abundance is significantly associated with the RNA expression of many other genes, with 5,078 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEC61G-associated genes across cancer lineages are KIF3B, KRT18, and ZNF143. Each is linked with SEC61G in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC61G-to-partner and partner-to-SEC61G results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC61G versus KIF3B in BRCA, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61G→partner) and Y-score (partner→SEC61G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF3B →	-0.584	-0.643	<.001	<.001	3	3
BRCA	KRT18 →	-1.013	-0.598	.002	<.001	3	3
BRCA	ZNF143 →	-0.325	-0.525	<.001	<.001	3	3
LSCC	COX5B →	-0.389	-0.279	.002	.003	3	3
OV	FOXN3P2 →	+0.507	+0.357	.005	<.001	3	2
OV	TRBV7-4 →	+0.764	+0.352	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,078 associations by consensus.

SEC61G vs KIF3B — BRCA

Explore this scatter interactively →