SEC61G

Across TCGA patient cohorts, SEC61G mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC61G-associated genes across cancer lineages are MTCO3P42, HNRNPMP2, and MIR147A. Each is linked with SEC61G in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61G-to-partner and partner-to-SEC61G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P42 grouped by SEC61G-low versus SEC61G-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61G→partner) and Y-score (partner→SEC61G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTCO3P42 →	+0.112	+5.362	<.001	.005	3	1
SKCM	HNRNPMP2 →	+0.065	+5.680	<.001	.003	3	1
COAD	MIR147A →	+0.655	+5.893	<.001	.002	3	1
COAD	GTF2F2P2 →	+0.192	+5.790	.001	.003	3	1
COAD	RNU7-96P →	+0.917	+5.516	.001	.004	3	1
COAD	TMF1P1 →	+0.263	+5.435	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

MTCO3P42 by SEC61G expression — SKCM

Explore this box plot interactively →