SEC61G-DT

Across TCGA pan-cancer cohorts, SEC61G-DT RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SEC61G-DT data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SEC61G-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SEC61G-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and UVM show a favorable association.

UCS, KICH, and HNSC are the cancer types where SEC61G-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.690	0.179	.001	48	view →
KICH	OS	Median	III,IV	0.468	1.000	.001	38	view →
HNSC	DFS	Quartile	All	0.234	0.438	.003	38	view →
UVM	DFS	Quartile	II,III,IV	0.840	0.431	.002	28	view →
SKCM	DFS	Tertile	IV	0.857	0.073	.001	28	view →
CHOL	DFS	Tertile	IV	0.950	0.406	.040	18	view →
CESC	OS	Median	IV	0.855	0.389	.008	12	view →
TGCT	DFS	Median	All	0.924	0.742	.003	12	view →
ACC	OS	Tertile	IV	0.850	0.217	.024	12	view →
ESCA	DFS	Median	II,III,IV	1.000	0.388	.010	9	view →
DLBC	OS	Median	All	0.630	1.000	.038	7	view →
LIHC	DFS	Quartile	All	0.268	0.472	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SEC61G-DT–UCS (DFS)

Open the UCS breakdown →