SEC61G-DT

Across TCGA pan-cancer cohorts, SEC61G-DT RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SEC61G-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SEC61G-DT RNA is repressed in tumor relative to normal tissue. In most cancer types SEC61G-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and BLCA are the cancer types where SEC61G-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC61G-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.474	<.001	6	view →
THCA	Male	All	−0.395	<.001	5	view →
BLCA	Male	All	+0.218	.029	4	view →
HNSC	All	All	+0.190	.009	3	view →
STAD	Male	All	+0.101	.046	1	view →
KIRC	All	All	−0.079	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SEC61G-DT–KICH

Open the KICH breakdown →