SEC61A2

Across TCGA pan-cancer cohorts, SEC61A2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SEC61A2 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEC61A2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEC61A2 expression acts as an unfavorable survival marker.

LUAD and PDAC are the cancer types where SEC61A2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.220	0.880	.013	5	view →
PDAC	DFS	Median	All	0.203	0.647	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SEC61A2–LUAD (OS)

Open the LUAD breakdown →