SEC61A2

Across TCGA patient cohorts, SEC61A2 mutation is significantly associated with the RNA expression of many other genes, with 1,132 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC61A2-associated genes across cancer lineages are LINC01853, LINC02353, and MIR6803. Each is linked with SEC61A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61A2-to-partner and partner-to-SEC61A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01853 grouped by SEC61A2-low versus SEC61A2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A2→partner) and Y-score (partner→SEC61A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01853 →	+0.068	+6.584	<.001	<.001	3	2
CESC	LINC02353 →	+0.038	+4.669	<.001	.007	3	2
UCEC	MIR6803 →	+0.144	+4.390	<.001	.003	3	2
UCEC	TRAJ29 →	+0.519	+2.446	<.001	.001	3	2
UCEC	TAF11L14 →	+0.273	+2.100	<.001	.002	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,132 associations by consensus.

LINC01853 by SEC61A2 expression — CESC

Explore this box plot interactively →