SEC61A2

Across TCGA patient cohorts, SEC61A2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC61A2-associated genes across cancer lineages are ASNS, 14-3-3_beta, and A-Raf_pS299. Each is linked with SEC61A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61A2-to-partner and partner-to-SEC61A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SEC61A2-low versus SEC61A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A2→partner) and Y-score (partner→SEC61A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.463	+2.999	.004	.035	3	2
UCEC	14-3-3_beta →	-0.110	-2.973	.015	.035	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.000	.013	.032	3	1
UCEC	ERK2 →	+0.201	+3.321	.020	.010	3	1
UCEC	JNK2 →	+0.277	+3.807	.001	<.001	3	1
UCEC	p27_pT157 →	-0.055	-2.282	.033	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ASNS by SEC61A2 expression — UCEC

Explore this box plot interactively →