SEC61A2

Across TCGA cell cohorts, SEC61A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,544 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC61A2-associated GO terms across cancer lineages are Regulation of microtubule-based process, Centrosome cycle, and Protein localization to cilium. Each is linked with SEC61A2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SEC61A2-to-partner and partner-to-SEC61A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of microtubule-based process grouped by SEC61A2-low versus SEC61A2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A2→partner) and Y-score (partner→SEC61A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of microtubule-based process →	+0.060	+0.914	<.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.089	+0.762	.001	.003	2	14
LUNG_NSCLC_LUAD	Protein localization to cilium →	+0.065	+1.026	<.001	<.001	3	13
BREAST	Microtubule organizing center organization →	+0.069	+0.858	<.001	<.001	2	14
LARGE_INTESTINE	Regulation of organelle assembly →	+0.036	+0.804	.002	.006	3	12
BREAST	Positive regulation of cilium assembly →	+0.091	+0.730	.002	.008	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,544 associations by consensus.

Regulation of microtubule-based process by SEC61A2 expression — LUNG_SCLC

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