SEC61A2

Across TCGA cell cohorts, SEC61A2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SEC61A2-associated genes across cancer lineages are HSFY2, GSG1L2, and ZPBP2. Each is linked with SEC61A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61A2-to-partner and partner-to-SEC61A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by SEC61A2-low versus SEC61A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A2→partner) and Y-score (partner→SEC61A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.026	+6.022	<.001	.001	3	1
CNS	ZPBP2 →	+0.089	+5.754	<.001	.002	3	1
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	1
CNS	LEUTX →	+0.223	+5.321	<.001	.005	3	1
CNS	CELA3B →	+0.182	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HSFY2 by SEC61A2 expression — LARGE_INTESTINE

Explore this box plot interactively →