SEC31B

Across TCGA patient cohorts, SEC31B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC31B-associated genes across cancer lineages are Notch1, CD20, and FoxM1. Each is linked with SEC31B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC31B-to-partner and partner-to-SEC31B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SEC31B-low versus SEC31B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC31B→partner) and Y-score (partner→SEC31B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.130	+1.473	.002	.006	3	3
UCEC	CD20 →	+0.094	+1.267	.019	.026	3	3
STAD	FoxM1 →	+0.359	+2.838	.005	.033	3	2
STAD	FOXO3a_pS318_S321 →	-0.229	-3.148	.011	.019	3	2
UCEC	Cyclin-B1 →	+0.435	+2.700	.011	.005	3	2
UCEC	eEF2 →	+0.308	+2.906	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by SEC31B expression — UCEC

Explore this box plot interactively →