SEC31B

Across TCGA pan-cancer cohorts, SEC31B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SEC31B’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SEC31B RNA is repressed in tumor relative to normal tissue. In most cancer types SEC31B is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.

BRCA, COAD, and LUSC are the cancer types where SEC31B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC31B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.943	<.001	6	view →
COAD	All	II,III,IV	+0.480	.001	5	view →
LUSC	All	All	−0.466	.001	5	view →
KIRC	All	All	+0.249	.003	5	view →
LIHC	All	All	+0.263	.003	4	view →
HNSC	Male	All	−0.364	.015	2	view →
KICH	All	All	−0.314	.009	2	view →
CHOL	All	All	+0.949	.004	1	view →
READ	All	All	+0.550	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SEC31B–BRCA

Open the BRCA breakdown →