SEC31B

Across TCGA cell cohorts, SEC31B mutation is significantly associated with the RNA expression of many other genes, with 924 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC31B-associated genes across cancer lineages are RFPL3, PARP2, and PPEF2. Each is linked with SEC31B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC31B-to-partner and partner-to-SEC31B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by SEC31B-low versus SEC31B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC31B→partner) and Y-score (partner→SEC31B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RFPL3 →	+0.054	+4.339	<.001	.002	3	2
LARGE_INTESTINE	PARP2 →	+0.548	+3.169	.002	.009	3	2
LARGE_INTESTINE	PPEF2 →	+0.024	+2.222	.001	.002	3	2
LARGE_INTESTINE	MBOAT4 →	+0.134	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	HBG1 →	+0.054	+1.691	.003	.009	3	2
LARGE_INTESTINE	ADSS2 →	+0.506	+3.321	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 924 associations by consensus.

RFPL3 by SEC31B expression — BLOOD_Leukemia

Explore this box plot interactively →