SEC31A

Across TCGA pan-cancer cohorts, SEC31A mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SEC31A data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SEC31A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC31A expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where SEC31A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.623	0.913	<.001	52	view →
UCEC	DFS	Quartile	All	0.967	0.707	.004	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
CCRCC	OS	Median	All	0.903	1.000	.013	7	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
HNSC	DFS	Median	III,IV	0.876	0.697	.018	6	view →
GBM	DFS	Quartile	All	0.640	0.778	.038	1	view →
LUAD	DFS	Median	All	0.902	0.897	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SEC31A–LSCC (DFS)

Open the LSCC breakdown →